Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis

Our previous studies revealed that sesamin caused a mechanism-based inhibition (MBI) of CYP2C9 in human liver microsomes. Additionally, we observed a similar MBI of CYP2C by sesamin in the rat liver microsomes. Sesamin-induced difference spectra of rat or human liver microsomes in the presence of NA...

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Detalles Bibliográficos
Autores principales: Yasuda, Kaori, Ueno, Sera, Ueda, Erika, Nishikawa, Miyu, Takeda, Kie, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618645/
https://www.ncbi.nlm.nih.gov/pubmed/26516586
http://dx.doi.org/10.1002/prp2.174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618645/
https://www.ncbi.nlm.nih.gov/pubmed/26516586
http://dx.doi.org/10.1002/prp2.174

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