A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. Here, we present a simple method to identify the GAG-binding site (GBS) on proteins th...

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Detalles Bibliográficos
Autores principales: Sarkar, Aurijit, Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619353/
https://www.ncbi.nlm.nih.gov/pubmed/26488293
http://dx.doi.org/10.1371/journal.pone.0141127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619353/
https://www.ncbi.nlm.nih.gov/pubmed/26488293
http://dx.doi.org/10.1371/journal.pone.0141127

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