Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance

The evolution of hypermutators in response to antibiotic treatment in both clinical and laboratory settings provides a unique context for the study of adaptive evolution. With increased mutation rates, the number of hitchhiker mutations within an evolving hypermutator population is remarkably high a...

Descripción completa

Detalles Bibliográficos
Autores principales: Hammerstrom, Troy G., Beabout, Kathryn, Clements, Thomas P., Saxer, Gerda, Shamoo, Yousif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619398/
https://www.ncbi.nlm.nih.gov/pubmed/26488727
http://dx.doi.org/10.1371/journal.pone.0140489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619398/
https://www.ncbi.nlm.nih.gov/pubmed/26488727
http://dx.doi.org/10.1371/journal.pone.0140489

Ejemplares similares