Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes

BACKGROUND: Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory gene transcription respectively. HDAC2 is required by corticosteroids to switch off activated inflammatory genes and is reduced in lung macrophages in COPD. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Hodge, Greg, Jersmann, Hubertus, Tran, Hai B., Roscioli, Eugene, Holmes, Mark, Reynolds, Paul N., Hodge, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619495/
https://www.ncbi.nlm.nih.gov/pubmed/26498345
http://dx.doi.org/10.1186/s12931-015-0287-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619495/
https://www.ncbi.nlm.nih.gov/pubmed/26498345
http://dx.doi.org/10.1186/s12931-015-0287-2

Ejemplares similares