Cargando…

Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes

BACKGROUND: Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory gene transcription respectively. HDAC2 is required by corticosteroids to switch off activated inflammatory genes and is reduced in lung macrophages in COPD. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hodge, Greg, Jersmann, Hubertus, Tran, Hai B., Roscioli, Eugene, Holmes, Mark, Reynolds, Paul N., Hodge, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619495/ https://www.ncbi.nlm.nih.gov/pubmed/26498345 http://dx.doi.org/10.1186/s12931-015-0287-2

Ejemplares similares

Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes
por: Hodge, Greg, et al.
Publicado: (2020)

Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes
por: Hodge, Greg, et al.
Publicado: (2015)

Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes
por: Hodge, Greg, et al.
Publicado: (2016)

BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?
por: Hodge, Greg, et al.
Publicado: (2023)

The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD
por: Hodge, Greg, et al.
Publicado: (2013)

Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD
por: Hodge, Greg, et al.
Publicado: (2014)

Bushfire smoke is pro-inflammatory and suppresses macrophage phagocytic function
por: Hamon, Rhys, et al.
Publicado: (2018)

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)
por: Barnawi, Jameel, et al.
Publicado: (2015)

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD
por: Tran, Hai B., et al.
Publicado: (2017)

Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD
por: Roscioli, Eugene, et al.
Publicado: (2018)

Lectins Offer New Perspectives in the Development of Macrophage-Targeted Therapies for COPD/Emphysema
por: Mukaro, Violet R., et al.
Publicado: (2013)

Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke
por: Asare, Patrick F., et al.
Publicado: (2021)

Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD
por: Roscioli, Eugene, et al.
Publicado: (2017)

Oxidative Stress Decreases Functional Airway Mannose Binding Lectin in COPD
por: Tran, Hai B., et al.
Publicado: (2014)

Defective Lung Macrophage Function in Lung Cancer±Chronic Obstructive Pulmonary Disease (COPD/Emphysema)-Mediated by Cancer Cell Production of PGE2?
por: Dehle, Francis C., et al.
Publicado: (2013)

Zinc and Zinc Transporters in Macrophages and Their Roles in Efferocytosis in COPD
por: Hamon, Rhys, et al.
Publicado: (2014)

Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis
por: Hodge, G., et al.
Publicado: (2015)

Histone deacetylase activity is decreased in peripheral blood monocytes in patients with COPD
por: Chen, Yanwei, et al.
Publicado: (2012)

Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors
por: Sahu, Gautam K, et al.
Publicado: (2011)

COPD-Related Modification to the Airway Epithelium Permits Intracellular Residence of Nontypeable Haemophilus influenzae and May Be Potentiated by Macrolide Arrest of Autophagy
por: Poh, Wee-Peng, et al.
Publicado: (2020)

Therapeutic Targeting Steroid Resistant Pro-Inflammatory NK and NKT-Like Cells in Chronic Inflammatory Lung Disease
por: Hodge, Greg, et al.
Publicado: (2019)

Steroid Resistant CD8(+)CD28(null) NKT-Like Pro-inflammatory Cytotoxic Cells in Chronic Obstructive Pulmonary Disease
por: Hodge, Greg, et al.
Publicado: (2016)

AIM2 nuclear exit and inflammasome activation in chronic obstructive pulmonary disease and response to cigarette smoke
por: Tran, Hai B., et al.
Publicado: (2021)

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes
por: Jones, Richard Brad, et al.
Publicado: (2014)

Histone deacetylases 1 and 2 restrain CD4(+) cytotoxic T lymphocyte differentiation
por: Preglej, Teresa, et al.
Publicado: (2020)

Decreased Histone Deacetylase 2 (HDAC2) in Peripheral Blood Monocytes (PBMCs) of COPD Patients
por: Tan, Chunting, et al.
Publicado: (2016)

Correction: Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes
Publicado: (2014)

LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness
por: Asare, Patrick F., et al.
Publicado: (2020)

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD
por: Footitt, Joseph, et al.
Publicado: (2016)

Organotypic sinonasal airway culture systems are predictive of the mucociliary phenotype produced by bronchial airway epithelial cells
por: Delhove, Juliette, et al.
Publicado: (2022)

Phosphoproteomic analysis reveals an intrinsic pathway for histone deacetylase 7 regulation that controls cytotoxic T lymphocyte function
por: Navarro, Maria N., et al.
Publicado: (2011)

The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines
por: Klein, Jan M., et al.
Publicado: (2013)

Chidamide, a histone deacetylase inhibitor, inhibits autophagy and exhibits therapeutic implication in chronic lymphocytic leukemia
por: Kong, Yi-Lin, et al.
Publicado: (2020)

PB1856: DEMETHYLATING AGENTS AND HISTONE DEACETYLASE INHIBITORS AS NEW THERAPEUTIC STRATEGIES IN CHRONIC LYMPHOCYTIC LEUKEMIA
por: Jorge #, J., et al.
Publicado: (2022)

Histone Deacetylase Inhibitors Restore Cancer Cell Sensitivity towards T Lymphocytes Mediated Cytotoxicity in Pancreatic Cancer
por: Looi, Chin-King, et al.
Publicado: (2022)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages
por: Cosio, Borja G., et al.
Publicado: (2004)

Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells
por: Zhou, Qingjun, et al.
Publicado: (2008)

Inhibitors of histone deacetylase 1 reverse the immune evasion phenotype to enhance T-cell mediated lysis of prostate and breast carcinoma cells
por: Gameiro, Sofia R., et al.
Publicado: (2016)

Changes in Airway Histone Deacetylase2 in Smokers and COPD with Inhaled Corticosteroids: A Randomized Controlled Trial
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_8lk0a9q1fc3c8hdc09d0er9ia8