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Inhibition of Matriptase Activity Results in Decreased Intestinal Epithelial Monolayer Integrity In Vitro

Barrier dysfunction in inflammatory bowel diseases implies enhanced paracellular flux and lowered transepithelial electrical resistance (TER) causing effective invasion of enteropathogens or altered intestinal absorption of toxins and drug compounds. To elucidate the role of matriptase-driven cell s...

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Detalles Bibliográficos
Autores principales: Pászti-Gere, E., McManus, S., Meggyesházi, N., Balla, P., Gálfi, P., Steinmetzer, T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619522/
https://www.ncbi.nlm.nih.gov/pubmed/26488575
http://dx.doi.org/10.1371/journal.pone.0141077