TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines

BACKGROUND: The nerve growth factor (NGF) receptor tyrosine-kinase TrkA is a well-known determinant of the melanocytic lineage, through modulation of the MAPK and AKT cascades. While TrkA gene is frequently rearranged in cancers, its involvement in malignant melanoma (MM) development is still unclea...

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Detalles Bibliográficos
Autores principales: Pasini, Luigi, Re, Angela, Tebaldi, Toma, Ricci, Gianluca, Boi, Sebastiana, Adami, Valentina, Barbareschi, Mattia, Quattrone, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619539/
https://www.ncbi.nlm.nih.gov/pubmed/26496938
http://dx.doi.org/10.1186/s12885-015-1791-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619539/
https://www.ncbi.nlm.nih.gov/pubmed/26496938
http://dx.doi.org/10.1186/s12885-015-1791-y

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