PCR-Free Enrichment of Mitochondrial DNA from Human Blood and Cell Lines for High Quality Next-Generation DNA Sequencing

Recent advances in sequencing technology allow for accurate detection of mitochondrial sequence variants, even those in low abundance at heteroplasmic sites. Considerable sequencing cost savings can be achieved by enriching samples for mitochondrial (relative to nuclear) DNA. Reduction in nuclear DN...

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Detalles Bibliográficos
Autores principales: Gould, Meetha P., Bosworth, Colleen M., McMahon, Sarah, Grandhi, Sneha, Grimerg, Brian T., LaFramboise, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619561/
https://www.ncbi.nlm.nih.gov/pubmed/26488301
http://dx.doi.org/10.1371/journal.pone.0139253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619561/
https://www.ncbi.nlm.nih.gov/pubmed/26488301
http://dx.doi.org/10.1371/journal.pone.0139253

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