Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer

OBJECTIVE: Celastrol has anti-cancer effects by increase of apoptosis of gastric cancer cells. However, its role in gastric cancer cell cycle is still unclear. The aim of this study was to investigate the effect and mechanism of celastrol on gastric cancer cell cycle. METHODS: The effects of celastr...

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Detalles Bibliográficos
Autores principales: Sha, Min, Ye, Jun, Luan, Zheng-yun, Guo, Ting, Wang, Bian, Huang, Jun-xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619578/
https://www.ncbi.nlm.nih.gov/pubmed/26500453
http://dx.doi.org/10.1186/s12935-015-0256-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619578/
https://www.ncbi.nlm.nih.gov/pubmed/26500453
http://dx.doi.org/10.1186/s12935-015-0256-3

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