TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway

TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th(1) polarized CD4(+) and CD8(+) T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent imm...

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Detalles Bibliográficos
Autores principales: Tomkowicz, Brian, Walsh, Eileen, Cotty, Adam, Verona, Raluca, Sabins, Nina, Kaplan, Fred, Santulli-Marotto, Sandy, Chin, Chen-Ni, Mooney, Jill, Lingham, Russell B., Naso, Michael, McCabe, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619610/
https://www.ncbi.nlm.nih.gov/pubmed/26492563
http://dx.doi.org/10.1371/journal.pone.0140694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619610/
https://www.ncbi.nlm.nih.gov/pubmed/26492563
http://dx.doi.org/10.1371/journal.pone.0140694

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