The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps

Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and N-acetyl-galactosamine (GalNAc) that mediates adherence and is required for full virulence...

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Autores principales: Lee, Mark J., Liu, Hong, Barker, Bridget M., Snarr, Brendan D., Gravelat, Fabrice N., Al Abdallah, Qusai, Gavino, Christina, Baistrocchi, Shane R., Ostapska, Hanna, Xiao, Tianli, Ralph, Benjamin, Solis, Norma V., Lehoux, Mélanie, Baptista, Stefanie D., Thammahong, Arsa, Cerone, Robert P., Kaminskyj, Susan G. W., Guiot, Marie-Christine, Latgé, Jean-Paul, Fontaine, Thierry, Vinh, Donald C., Filler, Scott G., Sheppard, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619649/
https://www.ncbi.nlm.nih.gov/pubmed/26492565
http://dx.doi.org/10.1371/journal.ppat.1005187