Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin

Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simplistic static binding models. Our study rationalizes...

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Detalles Bibliográficos
Autores principales: Fuchs, Julian E., Huber, Roland G., Waldner, Birgit J., Kahler, Ursula, von Grafenstein, Susanne, Kramer, Christian, Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619833/
https://www.ncbi.nlm.nih.gov/pubmed/26496636
http://dx.doi.org/10.1371/journal.pone.0140713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619833/
https://www.ncbi.nlm.nih.gov/pubmed/26496636
http://dx.doi.org/10.1371/journal.pone.0140713

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