Cargando…

Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin

Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simplistic static binding models. Our study rationalizes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuchs, Julian E., Huber, Roland G., Waldner, Birgit J., Kahler, Ursula, von Grafenstein, Susanne, Kramer, Christian, Liedl, Klaus R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619833/ https://www.ncbi.nlm.nih.gov/pubmed/26496636 http://dx.doi.org/10.1371/journal.pone.0140713

Ejemplares similares

Specificity of a protein–protein interface: Local dynamics direct substrate recognition of effector caspases
por: Fuchs, Julian E., et al.
Publicado: (2014)

Specificity of a protein–protein interface: Local dynamics direct substrate recognition of effector caspases
por: Fuchs, Julian E, et al.
Publicado: (2014)

Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases
por: Waldner, Birgit J., et al.
Publicado: (2015)

Electrostatic recognition in substrate binding to serine proteases
por: Waldner, Birgit J., et al.
Publicado: (2018)

Substrate-Driven Mapping of the Degradome by Comparison of Sequence Logos
por: Fuchs, Julian E., et al.
Publicado: (2013)

Characterizing Protease Specificity: How Many Substrates Do We Need?
por: Schauperl, Michael, et al.
Publicado: (2015)

Protease Inhibitors in View of Peptide Substrate Databases
por: Waldner, Birgit J., et al.
Publicado: (2016)

Sodium-induced population shift drives activation of thrombin
por: Kahler, Ursula, et al.
Publicado: (2020)

An unexpected switch in peptide binding mode: from simulation to substrate specificity
por: Kahler, Ursula, et al.
Publicado: (2018)

Interface dynamics explain assembly dependency of influenza neuraminidase catalytic activity
por: von Grafenstein, Susanne, et al.
Publicado: (2015)

Dynamic Regulation of Phenylalanine Hydroxylase by Simulated Redox Manipulation
por: Fuchs, Julian E., et al.
Publicado: (2012)

Heteroaromatic π-Stacking Energy Landscapes
por: Huber, Roland G., et al.
Publicado: (2014)

Binding Pose Flip Explained via Enthalpic and Entropic Contributions
por: Schauperl, Michael, et al.
Publicado: (2017)

Cleavage Entropy as Quantitative Measure of Protease Specificity
por: Fuchs, Julian E., et al.
Publicado: (2013)

Entropy from State Probabilities: Hydration Entropy of Cations
por: Huber, Roland G., et al.
Publicado: (2013)

Localization of Millisecond Dynamics: Dihedral Entropy from Accelerated MD
por: Kamenik, Anna S., et al.
Publicado: (2016)

Protein-Protein Binding as a Two-Step Mechanism: Preselection of Encounter Poses during the Binding of BPTI and Trypsin
por: Kahler, Ursula, et al.
Publicado: (2020)

Substrate Sequences Tell Similar Stories as Binding Cavities: Commentary
por: Fuchs, Julian E., et al.
Publicado: (2013)

Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility
por: Xu, Zhongli, et al.
Publicado: (2016)

Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data
por: Fuchs, Julian E., et al.
Publicado: (2017)

Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
por: Svetlova, Julia, et al.
Publicado: (2021)

FAH Domain Containing Protein 1 (FAHD-1) Is Required for Mitochondrial Function and Locomotion Activity in C. elegans
por: Taferner, Andrea, et al.
Publicado: (2015)

Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P
por: Brillante, Nadia, et al.
Publicado: (2016)

Strong Nonadditivity as a Key Structure–Activity Relationship Feature: Distinguishing Structural Changes from Assay Artifacts
por: Kramer, Christian, et al.
Publicado: (2015)

Substrate Recognition and Specificity of Double-Stranded RNA Binding Proteins
por: Vuković, Lela, et al.
Publicado: (2014)

Backbone flexibility controls the activity and specificity of a protein-protein interface – specificity in snake venom metalloproteases (SVMPs)
por: Wallnoefer, Hannes G, et al.
Publicado: (2011)

Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)
por: Weiss, Alexander K. H., et al.
Publicado: (2021)

Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12
por: Smirnov, Igor, et al.
Publicado: (2021)

Enthalpic and Entropic Contributions to Hydrophobicity
por: Schauperl, Michael, et al.
Publicado: (2016)

Catalytic Site pK(a) Values of Aspartic, Cysteine, and Serine Proteases: Constant pH MD Simulations
por: Hofer, Florian, et al.
Publicado: (2020)

A novel index of protein-protein interface propensity improves interface residue recognition
por: Dai, Wentao, et al.
Publicado: (2016)

Identification of Novel Liver X Receptor Activators by Structure-Based Modeling
por: von Grafenstein, Susanne, et al.
Publicado: (2012)

PEP-Patch: Electrostatics in Protein–Protein Recognition, Specificity, and Antibody Developability
por: Hoerschinger, Valentin J., et al.
Publicado: (2023)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
por: Chahal, Gurdeep, et al.
Publicado: (2015)

SiteEngines: recognition and comparison of binding sites and protein–protein interfaces
por: Shulman-Peleg, Alexandra, et al.
Publicado: (2005)

Evolution of protein kinase substrate recognition at the active site
por: Bradley, David, et al.
Publicado: (2019)

Antibody recognition of the Pneumovirus fusion protein trimer interface
por: Huang, Jiachen, et al.
Publicado: (2020)

DNA Electric Charge Oscillations Govern Protein–DNA Recognition
por: Štěpánek, Josef, et al.
Publicado: (2015)

Protein Dynamics Governed by Interfaces of High Polarity and Low Packing Density
por: Angarica, Vladimir Espinosa, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_h0hshu9dufiepot939ed37pm73