How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective

The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry c...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Chiang, ChienWei, Liang, Hong, Wu, Hengyi, Feng, Weixing, Quinney, Sara K., Li, Jin, Li, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619875/
https://www.ncbi.nlm.nih.gov/pubmed/26539530
http://dx.doi.org/10.1155/2015/857327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619875/
https://www.ncbi.nlm.nih.gov/pubmed/26539530
http://dx.doi.org/10.1155/2015/857327

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