Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway

BACKGROUND: Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to evaluate whether 5-aza-2-deoxycytidine (5-aza-2-dC) can reverse methylation of the...

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Detalles Bibliográficos
Autores principales: Ho, Chih-Ming, Huang, Chi-Jung, Huang, Shih-Hung, Chang, Shwu-Fen, Cheng, Wen-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619992/
https://www.ncbi.nlm.nih.gov/pubmed/26497956
http://dx.doi.org/10.1186/s12885-015-1744-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619992/
https://www.ncbi.nlm.nih.gov/pubmed/26497956
http://dx.doi.org/10.1186/s12885-015-1744-5

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