Cargando…

Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway

BACKGROUND: Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to evaluate whether 5-aza-2-deoxycytidine (5-aza-2-dC) can reverse methylation of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Chih-Ming, Huang, Chi-Jung, Huang, Shih-Hung, Chang, Shwu-Fen, Cheng, Wen-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619992/ https://www.ncbi.nlm.nih.gov/pubmed/26497956 http://dx.doi.org/10.1186/s12885-015-1744-5

Ejemplares similares

Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma
por: Ho, Chih-Ming, et al.
Publicado: (2012)

CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Analysis of mTOR Inhibition-Involved Pathway in Ovarian Clear Cell Adenocarcinoma
por: Harasawa, Makiko, et al.
Publicado: (2011)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2022)

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma
por: Zi, Dan, et al.
Publicado: (2023)

HIN-1, an inhibitor of cell growth, invasion, and AKT1 activation
por: Krop, IE, et al.
Publicado: (2005)

Roles of Akt and ERK in mTOR-Dependent Antidepressant Effects of Vanillic Acid
por: Chuang, Han-Wen, et al.
Publicado: (2020)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells
por: Gao, Likun, et al.
Publicado: (2019)

AZD2014 Radiosensitizes Oral Squamous Cell Carcinoma by Inhibiting AKT/mTOR Axis and Inducing G1/G2/M Cell Cycle Arrest
por: Yu, Chih-Chia, et al.
Publicado: (2016)

Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer
por: Chen, Hongrun, et al.
Publicado: (2023)

PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin-3-gallate in ovarian cancer
por: Qin, Jianli, et al.
Publicado: (2020)

Nitidine Chloride Triggers Autophagy and Apoptosis of Ovarian Cancer Cells through Akt/mTOR Signaling Pathway
por: Lian, Chaoqun, et al.
Publicado: (2023)

Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitro and in vivo
por: Yu, Chih-Chia, et al.
Publicado: (2017)

DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway
por: Li, Meng, et al.
Publicado: (2022)

Morphology, clearing efficacy, and mTOR dependency of the organelle autophagoproteasome
por: Limanaqi, Fiona, et al.
Publicado: (2021)

Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators
por: Cheng, Yuan, et al.
Publicado: (2015)

The PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challenges
por: Cheaib, Bianca, et al.
Publicado: (2015)

Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells
por: Duan, Jingya, et al.
Publicado: (2023)

Targeting Mps1 in combination with paclitaxel inhibits osteosarcoma progression by modulating spindle assembly checkpoint and Akt/mTOR signaling
por: Lu, Lu, et al.
Publicado: (2021)

AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer
por: Hung, Ming-Chun, et al.
Publicado: (2022)

Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule
por: Zhuang, Ze, et al.
Publicado: (2019)

Reversing Melanoma Cross-Resistance to BRAF and MEK Inhibitors by Co-Targeting the AKT/mTOR Pathway
por: Atefi, Mohammad, et al.
Publicado: (2011)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines
por: Lin, Hugo You-Hsien, et al.
Publicado: (2014)

Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis
por: Ho, Chih-Ming, et al.
Publicado: (2015)

Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway
por: HE, FAN, et al.
Publicado: (2014)

PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer
por: Aziz, Aziz Ur Rehman, et al.
Publicado: (2018)

PI3K/AKT/mTOR Pathway in Ovarian Cancer Treatment: Are We on the Right Track?
por: Gasparri, Maria Luisa, et al.
Publicado: (2017)

Targeting the PI3K/AKT/mTOR/NFκB Axis in Ovarian Cancer
por: Ghoneum, Alia, et al.
Publicado: (2020)

Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer
por: Luan, Wenqing, et al.
Publicado: (2019)

mTOR-sensitive translation: Cleared fog reveals more trees
por: Masvidal, Laia, et al.
Publicado: (2017)

mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update
por: Limanaqi, Fiona, et al.
Publicado: (2020)

Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma
por: Fan, Demin, et al.
Publicado: (2020)

Epidemiology and Outcomes of HIN1 Pneumonia in ICU
por: Golagana, Vinya, et al.
Publicado: (2023)

Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs: Effect of Akt/mTOR inhibition on PTEN expression
por: Wan, Linyan, et al.
Publicado: (2022)

Reversing autism by targeting downstream mTOR signaling
por: Wang, Hansen, et al.
Publicado: (2013)

Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway
por: Chen, Dongshao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6d9f2dd6akphon466qr5kcgft6