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Chelating effect in short polymers for the design of bidentate binders of increased affinity and selectivity
The design of new strong and selective binders is a key step towards the development of new sensing devices and effective drugs. Both affinity and selectivity can be increased through chelation and here we theoretically explore the possibility of coupling two binders through a flexible linker. We pr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620483/ https://www.ncbi.nlm.nih.gov/pubmed/26496975 http://dx.doi.org/10.1038/srep15633 |