The cell cycle inhibitor Cdkn1a regulates Langerhans cell radiation resistance and promotes T regulatory cell generation upon exposure to ionizing irradiation

Treatment with ionizing irradiation (IR) may lead to accumulation of tumor-infiltrating T regulatory (T(reg)) cells and subsequent tumor resistance to radiotherapy. Here we focused on the contribution of the epidermal mononuclear phagocytes, Langerhans cells (LCs), to this phenomenon because of thei...

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Detalles Bibliográficos
Autores principales: Price, Jeremy G., Idoyaga, Juliana, Salmon, Hélène, Hogstad, Brandon, Bigarella, Carolina L., Ghaffari, Saghi, Leboeuf, Marylene, Merad, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620552/
https://www.ncbi.nlm.nih.gov/pubmed/26343536
http://dx.doi.org/10.1038/ni.3270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620552/
https://www.ncbi.nlm.nih.gov/pubmed/26343536
http://dx.doi.org/10.1038/ni.3270

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