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The cell cycle inhibitor Cdkn1a regulates Langerhans cell radiation resistance and promotes T regulatory cell generation upon exposure to ionizing irradiation
Treatment with ionizing irradiation (IR) may lead to accumulation of tumor-infiltrating T regulatory (T(reg)) cells and subsequent tumor resistance to radiotherapy. Here we focused on the contribution of the epidermal mononuclear phagocytes, Langerhans cells (LCs), to this phenomenon because of thei...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620552/ https://www.ncbi.nlm.nih.gov/pubmed/26343536 http://dx.doi.org/10.1038/ni.3270 |