A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma

BACKGROUND: Many human tumors show aberrant activation of a group of germline-specific genes, termed cancer-germline (CG) genes, several of which appear to exert oncogenic functions. Although activation of CG genes in tumors has been linked to promoter DNA demethylation, the mechanisms underlying th...

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Detalles Bibliográficos
Autores principales: Cannuyer, Julie, Van Tongelen, Aurélie, Loriot, Axelle, De Smet, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620642/
https://www.ncbi.nlm.nih.gov/pubmed/26504497
http://dx.doi.org/10.1186/s13148-015-0147-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620642/
https://www.ncbi.nlm.nih.gov/pubmed/26504497
http://dx.doi.org/10.1186/s13148-015-0147-4

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