Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy

Platinum-based chemotherapy is the cornerstone of ovarian cancer treatment, and its efficacy is dependent on the generation of DNA damage, with subsequent induction of apoptosis. Inappropriate or aberrant activation of the DNA damage response network is associated with resistance to platinum, and de...

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Detalles Bibliográficos
Autores principales: Dungl, Daniela A., Maginn, Elaina N., Stronach, Euan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620694/
https://www.ncbi.nlm.nih.gov/pubmed/26579492
http://dx.doi.org/10.3389/fonc.2015.00240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620694/
https://www.ncbi.nlm.nih.gov/pubmed/26579492
http://dx.doi.org/10.3389/fonc.2015.00240

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