Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation

A novel class of phthalimides functionalized with privileged scaffolds was designed, synthesized and evaluated as potential inhibitors of plasmepsin 2 (K(i): 0.99 ± 0.1 μM for 6u) and plasmepsin 4 (K(i): 3.3 ± 0.3 μM for 6t), enzymes found in the digestive vacuole of the plasmodium parasite and cons...

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Detalles Bibliográficos
Autores principales: Singh, Anil K., Rathore, Sumit, Tang, Yan, Goldfarb, Nathan E., Dunn, Ben M., Rajendran, Vinoth, Ghosh, Prahlad C., Singh, Neelu, Latha, N., Singh, Brajendra K., Rawat, Manmeet, Rathi, Brijesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621027/
https://www.ncbi.nlm.nih.gov/pubmed/26502278
http://dx.doi.org/10.1371/journal.pone.0139347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621027/
https://www.ncbi.nlm.nih.gov/pubmed/26502278
http://dx.doi.org/10.1371/journal.pone.0139347

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