Cargando…

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

Nuclear pore complexes (NPCs) form a selective filter that allows the rapid passage of transport factors (TFs) and their cargoes across the nuclear envelope, while blocking the passage of other macromolecules. Intrinsically disordered proteins (IDPs) containing phenylalanyl-glycyl (FG)-rich repeats...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hough, Loren E, Dutta, Kaushik, Sparks, Samuel, Temel, Deniz B, Kamal, Alia, Tetenbaum-Novatt, Jaclyn, Rout, Michael P, Cowburn, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621360/ https://www.ncbi.nlm.nih.gov/pubmed/26371551 http://dx.doi.org/10.7554/eLife.10027

Ejemplares similares

Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo
por: Timney, Benjamin L., et al.
Publicado: (2006)

A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies
por: Zahn, Raphael, et al.
Publicado: (2016)

Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors
por: Andersen, Kasper R, et al.
Publicado: (2013)

A near atomic structure of the active human apoptosome
por: Cheng, Tat Cheung, et al.
Publicado: (2016)

An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
por: Boucher, Jeffrey I, et al.
Publicado: (2014)

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
por: Dambacher, Corey M, et al.
Publicado: (2016)

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
por: Fung, Ho Yee Joyce, et al.
Publicado: (2017)

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters
por: Verdon, Grégory, et al.
Publicado: (2014)

Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters
por: Cheng, Mary Hongying, et al.
Publicado: (2017)

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization
por: Sun, Siyang, et al.
Publicado: (2013)

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles
por: Bai, Xiao-chen, et al.
Publicado: (2013)

Large-scale state-dependent membrane remodeling by a transporter protein
por: Zhou, Wenchang, et al.
Publicado: (2019)

Intraflagellar transport drives flagellar surface motility
por: Shih, Sheng Min, et al.
Publicado: (2013)

Exploring conformational equilibria of a heterodimeric ABC transporter
por: Timachi, M Hadi, et al.
Publicado: (2017)

Reconstitution of dynein transport to the microtubule plus end by kinesin
por: Roberts, Anthony J, et al.
Publicado: (2014)

Atomic model of the F(420)-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector
por: Allegretti, Matteo, et al.
Publicado: (2014)

The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses
por: Agirrezabala, Xabier, et al.
Publicado: (2015)

Structure of the transporter associated with antigen processing trapped by herpes simplex virus
por: Oldham, Michael L, et al.
Publicado: (2016)

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex
por: Vovk, Andrei, et al.
Publicado: (2016)

Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner
por: Lowe, Alan R, et al.
Publicado: (2015)

Single-fluorophore membrane transport activity sensors with dual-emission read-out
por: Ast, Cindy, et al.
Publicado: (2015)

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
por: Chubanov, Vladimir, et al.
Publicado: (2016)

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
por: Wang, Zhao, et al.
Publicado: (2017)

Large-scale microtubule networks contract quite well
por: Belmonte, Julio M, et al.
Publicado: (2016)

The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA
por: Booth, David S, et al.
Publicado: (2014)

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
por: Derebe, Mehabaw G, et al.
Publicado: (2014)

Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter
por: Khantwal, Chandra M, et al.
Publicado: (2016)

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
por: Atherton, Joseph, et al.
Publicado: (2014)

Large-scale determination of previously unsolved protein structures using evolutionary information
por: Ovchinnikov, Sergey, et al.
Publicado: (2015)

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition
por: Kondo, Yasushi, et al.
Publicado: (2015)

Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis
por: Malinverni, Duccio, et al.
Publicado: (2017)

Mechanism of substrate binding and transport in BASS transporters
por: Becker, Patrick, et al.
Publicado: (2023)

The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain
por: Mysling, Simon, et al.
Publicado: (2016)

Binding and transport of D-aspartate by the glutamate transporter homolog Glt(Tk)
por: Arkhipova, Valentina, et al.
Publicado: (2019)

Improving the Hole Picture: Towards a Consensus on the Mechanism of Nuclear Transport
por: Cowburn, David, et al.
Publicado: (2023)

Improving the hole picture: towards a consensus on the mechanism of nuclear transport
por: Cowburn, David, et al.
Publicado: (2023)

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
por: Liu, Fei, et al.
Publicado: (2011)

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
por: Mitrea, Diana M, et al.
Publicado: (2016)

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1
por: Aznarez, Isabel, et al.
Publicado: (2018)

Challenges and solutions for the analysis of in situ, in crystallo micro-spectrophotometric data
por: Dworkowski, Florian S. N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_rav16q11ofd119mksgi8bj3oqc