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Early aggregation preceding the nucleation of insulin amyloid fibrils as monitored by small angle X-ray scattering
The nucleation event of amyloid fibrils is one of the most crucial processes that dictate the timing and rate of the pathology of diseases; however, information regarding how protein molecules associate to produce fibril nuclei is currently limited. In order to explore this issue in more detail, we...
Autores principales: | Chatani, Eri, Inoue, Rintaro, Imamura, Hiroshi, Sugiyama, Masaaki, Kato, Minoru, Yamamoto, Masahide, Nishida, Koji, Kanaya, Toshiji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621412/ https://www.ncbi.nlm.nih.gov/pubmed/26503463 http://dx.doi.org/10.1038/srep15485 |
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