Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Despite a strikingly similar amino acid sequence and predicted topology between these transporters, so...

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Detalles Bibliográficos
Autores principales: Andersen, Jacob, Ringsted, Kristoffer B., Bang-Andersen, Benny, Strømgaard, Kristian, Kristensen, Anders S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621520/
https://www.ncbi.nlm.nih.gov/pubmed/26503701
http://dx.doi.org/10.1038/srep15650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621520/
https://www.ncbi.nlm.nih.gov/pubmed/26503701
http://dx.doi.org/10.1038/srep15650

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