High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy

Loss of Purkinje cells has been implicated in the development of diabetic neuropathy, and this degeneration is characterized by impairment of autophagic processes. We evaluated whether fat-1 transgenic mice, a well-established animal model that endogenously synthesizes ω3 polyunsaturated fatty acids...

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Detalles Bibliográficos
Autores principales: Bak, Dong Ho, Zhang, Enji, Yi, Min-Hee, Kim, Do-Kyung, Lim, Kyu, Kim, Jwa-Jin, Kim, Dong Woon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621527/
https://www.ncbi.nlm.nih.gov/pubmed/26503303
http://dx.doi.org/10.1038/srep15465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621527/
https://www.ncbi.nlm.nih.gov/pubmed/26503303
http://dx.doi.org/10.1038/srep15465

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