PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase

The cytotoxicity of ionizing radiation depends on the cell cycle phase; therefore, its pharmacological manipulation, especially the induction of cell cycle arrest at the radiosensitive mitotic-phase (M-phase), has been attempted for effective radiation therapy. Polo-like kinase 1 (PLK1) is a serine/...

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Detalles Bibliográficos
Autores principales: Inoue, Minoru, Yoshimura, Michio, Kobayashi, Minoru, Morinibu, Akiyo, Itasaka, Satoshi, Hiraoka, Masahiro, Harada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621528/
https://www.ncbi.nlm.nih.gov/pubmed/26503893
http://dx.doi.org/10.1038/srep15666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621528/
https://www.ncbi.nlm.nih.gov/pubmed/26503893
http://dx.doi.org/10.1038/srep15666

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