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PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase
The cytotoxicity of ionizing radiation depends on the cell cycle phase; therefore, its pharmacological manipulation, especially the induction of cell cycle arrest at the radiosensitive mitotic-phase (M-phase), has been attempted for effective radiation therapy. Polo-like kinase 1 (PLK1) is a serine/...
Autores principales: | Inoue, Minoru, Yoshimura, Michio, Kobayashi, Minoru, Morinibu, Akiyo, Itasaka, Satoshi, Hiraoka, Masahiro, Harada, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621528/ https://www.ncbi.nlm.nih.gov/pubmed/26503893 http://dx.doi.org/10.1038/srep15666 |
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