A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, Marfan mice treated with CCBs show accelerated aneurysm expansion, rupture, and p...

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Detalles Bibliográficos
Autores principales: Doyle, Jefferson J, Doyle, Alexander J, Wilson, Nicole K, Habashi, Jennifer P, Bedja, Djahida, Whitworth, Ryan E, Lindsay, Mark E, Schoenhoff, Florian, Myers, Loretha, Huso, Nick, Bachir, Suha, Squires, Oliver, Rusholme, Benjamin, Ehsan, Hamid, Huso, David, Thomas, Craig J, Caulfield, Mark J, Van Eyk, Jennifer E, Judge, Daniel P, Dietz, Harry C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621743/
https://www.ncbi.nlm.nih.gov/pubmed/26506064
http://dx.doi.org/10.7554/eLife.08648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621743/
https://www.ncbi.nlm.nih.gov/pubmed/26506064
http://dx.doi.org/10.7554/eLife.08648

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