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The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition
Cortically anchored dynein orients the spindle through interactions with astral microtubules. In budding yeast, dynein is offloaded to Num1 receptors from microtubule plus ends. Rather than walking toward minus ends, dynein remains associated with plus ends due in part to its association with Pac1/L...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621840/ https://www.ncbi.nlm.nih.gov/pubmed/26483554 http://dx.doi.org/10.1083/jcb.201506119 |