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ERO1-independent production of H(2)O(2) within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

The endoplasmic reticulum (ER)–localized peroxiredoxin 4 (PRDX4) supports disulfide bond formation in eukaryotic cells lacking endoplasmic reticulum oxidase 1 (ERO1). The source of peroxide that fuels PRDX4-mediated disulfide bond formation has remained a mystery, because ERO1 is believed to be a ma...

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Detalles Bibliográficos
Autores principales:	Konno, Tasuku, Pinho Melo, Eduardo, Lopes, Carlos, Mehmeti, Ilir, Lenzen, Sigurd, Ron, David, Avezov, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621842/ https://www.ncbi.nlm.nih.gov/pubmed/26504166 http://dx.doi.org/10.1083/jcb.201506123

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