PP2A inhibitors arrest G2/M transition through JNK/Sp1-dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

Protein phosphatase 2A (PP2A) plays an important role in the control of the cell cycle. We previously reported that the PP2A inhibitors, cantharidin and okadaic acid (OA), efficiently repressed the growth of cancer cells. In the present study, we found that PP2A inhibitors arrested the cell cycle at...

Descripción completa

Detalles Bibliográficos
Autores principales: Gong, Fei-Ran, Wu, Meng-Yao, Shen, Meng, Zhi, Qiaoming, Xu, Ze-Kuan, Wang, Rong, Wang, Wen-Jie, Zong, Yang, Li, Zeng-Liang, Wu, Yadi, Zhou, Binhua P., Chen, Kai, Tao, Min, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621904/
https://www.ncbi.nlm.nih.gov/pubmed/26053095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621904/
https://www.ncbi.nlm.nih.gov/pubmed/26053095

Ejemplares similares