CEA/CD3 bispecific antibody MEDI-565/AMG 211 activation of T cells and subsequent killing of human tumors is independent of mutations commonly found in colorectal adenocarcinomas

Individual or combinations of somatic mutations found in genes from colorectal cancers can redirect the effects of chemotherapy and targeted agents on cancer cell survival and, consequently, on clinical outcome. Novel therapeutics with mechanisms of action that are independent of mutational status w...

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Detalles Bibliográficos
Autores principales: Oberst, Michael D, Fuhrmann, Stacy, Mulgrew, Kathy, Amann, Maria, Cheng, Lily, Lutterbuese, Petra, Richman, Laura, Coats, Steve, Baeuerle, Patrick A, Hammond, Scott A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622052/
https://www.ncbi.nlm.nih.gov/pubmed/25484061
http://dx.doi.org/10.4161/19420862.2014.975660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622052/
https://www.ncbi.nlm.nih.gov/pubmed/25484061
http://dx.doi.org/10.4161/19420862.2014.975660

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