A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life

Immunoglobulin G (IgG) has an unusually long serum half-life in comparison to proteins of a similar size. It is well-known that this phenomenon is due to IgG's ability to bind the neonatal Fc receptor (FcRn) in a pH-dependent manner. FcRn binding properties can vary among IgGs, resulting in alt...

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Detalles Bibliográficos
Autores principales: Souders, Colby A, Nelson, Stuart C, Wang, Yang, Crowley, Andrew R, Klempner, Mark S, Thomas, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622054/
https://www.ncbi.nlm.nih.gov/pubmed/26018774
http://dx.doi.org/10.1080/19420862.2015.1054585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622054/
https://www.ncbi.nlm.nih.gov/pubmed/26018774
http://dx.doi.org/10.1080/19420862.2015.1054585

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