Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

Human IgG is produced with C-terminal lysines that are cleaved off in circulation. The function of this modification was unknown and generally thought not to affect antibody function. We recently reported that efficient C1q binding and complement-dependent cytotoxicity (CDC) requires IgG hexamerizat...

Descripción completa

Detalles Bibliográficos
Autores principales: van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patrick HC, Parren, Paul WHI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622059/
https://www.ncbi.nlm.nih.gov/pubmed/26037225
http://dx.doi.org/10.1080/19420862.2015.1046665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622059/
https://www.ncbi.nlm.nih.gov/pubmed/26037225
http://dx.doi.org/10.1080/19420862.2015.1046665

Ejemplares similares