Improving target cell specificity using a novel monovalent bispecific IgG design

Monovalent bispecific IgGs cater to a distinct set of mechanisms of action but are difficult to engineer and manufacture because of complexities associated with correct heavy and light chain pairing. We have created a novel design, “DuetMab,” for efficient production of these molecules. The platform...

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Detalles Bibliográficos
Autores principales: Mazor, Yariv, Oganesyan, Vaheh, Yang, Chunning, Hansen, Anna, Wang, Jihong, Liu, Hongji, Sachsenmeier, Kris, Carlson, Marcia, Gadre, Dhanesh V, Borrok, Martin Jack, Yu, Xiang-Qing, Dall’Acqua, William, Wu, Herren, Chowdhury, Partha Sarathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622537/
https://www.ncbi.nlm.nih.gov/pubmed/25621507
http://dx.doi.org/10.1080/19420862.2015.1007816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622537/
https://www.ncbi.nlm.nih.gov/pubmed/25621507
http://dx.doi.org/10.1080/19420862.2015.1007816

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