A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical development. Oxidation of Fc methionines Met252 and Met428 is frequently observed, which leads to reduced affinity to FcRn and faster plasma clearanc...

Descripción completa

Detalles Bibliográficos
Autores principales: Stracke, Jan, Emrich, Thomas, Rueger, Petra, Schlothauer, Tilman, Kling, Lothar, Knaupp, Alexander, Hertenberger, Hubert, Wolfert, Andreas, Spick, Christian, Lau, Wilma, Drabner, Georg, Reiff, Ulrike, Koll, Hans, Papadimitriou, Apollon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622569/
https://www.ncbi.nlm.nih.gov/pubmed/25517308
http://dx.doi.org/10.4161/mabs.29601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622569/
https://www.ncbi.nlm.nih.gov/pubmed/25517308
http://dx.doi.org/10.4161/mabs.29601

Ejemplares similares