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A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical development. Oxidation of Fc methionines Met252 and Met428 is frequently observed, which leads to reduced affinity to FcRn and faster plasma clearanc...

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Detalles Bibliográficos
Autores principales:	Stracke, Jan, Emrich, Thomas, Rueger, Petra, Schlothauer, Tilman, Kling, Lothar, Knaupp, Alexander, Hertenberger, Hubert, Wolfert, Andreas, Spick, Christian, Lau, Wilma, Drabner, Georg, Reiff, Ulrike, Koll, Hans, Papadimitriou, Apollon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622569/ https://www.ncbi.nlm.nih.gov/pubmed/25517308 http://dx.doi.org/10.4161/mabs.29601

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