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Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer
The complement system is a powerful tool of the innate immune system to eradicate pathogens. Both in vitro and in vivo evidence indicates that therapeutic anti-tumor monoclonal antibodies (mAbs) can activate the complement system by the classical pathway. However, the contribution of complement to t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622586/ https://www.ncbi.nlm.nih.gov/pubmed/25517299 http://dx.doi.org/10.4161/mabs.29670 |