Functional assessment of antibody oxidation by native mass spectrometry

Oxidation of methionine (Met) residues is one of several chemical degradation pathways for recombinant IgG1 antibodies. Studies using several methodologies have indicated that Met oxidation in the constant IgG1 domains affects in vitro interaction with human neonatal Fc (huFcRn) receptor, which is i...

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Detalles Bibliográficos
Autores principales: Haberger, Markus, Heidenreich, Anna-Katharina, Schlothauer, Tilman, Hook, Michaela, Gassner, Jana, Bomans, Katrin, Yegres, Michelle, Zwick, Adrian, Zimmermann, Boris, Wegele, Harald, Bonnington, Lea, Reusch, Dietmar, Bulau, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622615/
https://www.ncbi.nlm.nih.gov/pubmed/26000623
http://dx.doi.org/10.1080/19420862.2015.1052199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622615/
https://www.ncbi.nlm.nih.gov/pubmed/26000623
http://dx.doi.org/10.1080/19420862.2015.1052199

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