Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs

Therapeutic antibodies must encompass drug product suitable attributes to be commercially marketed. An undesirable antibody characteristic is the propensity to aggregate. Although there are computational algorithms that predict the propensity of a protein to aggregate from sequence information alone...

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Detalles Bibliográficos
Autores principales: Clark, Rutilio H, Latypov, Ramil F, De Imus, Cyr, Carter, Jane, Wilson, Zien, Manchulenko, Kathy, Brown, Michael E, Ketchem, Randal R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622659/
https://www.ncbi.nlm.nih.gov/pubmed/25484048
http://dx.doi.org/10.4161/mabs.36252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622659/
https://www.ncbi.nlm.nih.gov/pubmed/25484048
http://dx.doi.org/10.4161/mabs.36252

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