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Remediating agitation-induced antibody aggregation by eradicating exposed hydrophobic motifs
Therapeutic antibodies must encompass drug product suitable attributes to be commercially marketed. An undesirable antibody characteristic is the propensity to aggregate. Although there are computational algorithms that predict the propensity of a protein to aggregate from sequence information alone...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622659/ https://www.ncbi.nlm.nih.gov/pubmed/25484048 http://dx.doi.org/10.4161/mabs.36252 |