Understanding the structural and dynamic consequences of DNA epigenetic modifications: Computational insights into cytosine methylation and hydroxymethylation

We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for t...

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Detalles Bibliográficos
Autores principales: Carvalho, Alexandra T P, Gouveia, Leonor, Kanna, Charan Raju, Wärmländer, Sebastian K T S, Platts, Jamie A, Kamerlin, Shina Caroline Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://www.ncbi.nlm.nih.gov/pubmed/25625845
http://dx.doi.org/10.4161/15592294.2014.988043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622728/
https://www.ncbi.nlm.nih.gov/pubmed/25625845
http://dx.doi.org/10.4161/15592294.2014.988043

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