High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...

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Detalles Bibliográficos
Autores principales: Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://www.ncbi.nlm.nih.gov/pubmed/26047159
http://dx.doi.org/10.1080/19420862.2015.1043503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622737/
https://www.ncbi.nlm.nih.gov/pubmed/26047159
http://dx.doi.org/10.1080/19420862.2015.1043503

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