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High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can often be impeded by developability issues such as poor expression, solubility,...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622737/ https://www.ncbi.nlm.nih.gov/pubmed/26047159 http://dx.doi.org/10.1080/19420862.2015.1043503 |