Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice

The products of the Slc12a1 and Slc12a2 genes, commonly known as Na(+)-dependent K(+)2Cl(−) co-transporters NKCC2 and NKCC1, respectively, are the targets for the diuretic bumetanide. NKCCs are implicated in the regulation of intracellular chloride concentration ([Cl(−)](i)) in pancreatic β-cells, a...

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Detalles Bibliográficos
Autores principales: Alshahrani, Saeed, Almutairi, Mohammed Mashari, Kursan, Shams, Dias-Junior, Eduardo, Almiahuob, Mohamed Mahmoud, Aguilar-Bryan, Lydia, Di Fulvio, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623298/
https://www.ncbi.nlm.nih.gov/pubmed/26400961
http://dx.doi.org/10.1530/JOE-15-0327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623298/
https://www.ncbi.nlm.nih.gov/pubmed/26400961
http://dx.doi.org/10.1530/JOE-15-0327

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