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miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively
miRNAs typically downregulate the expression of target genes by binding to their 3′UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3′UTR of hTERT mRNA and have opposite effects on the expression an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623477/ https://www.ncbi.nlm.nih.gov/pubmed/26507454 http://dx.doi.org/10.1038/srep15793 |