ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations

The increased risk of developing Alzheimer’s disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 an...

Descripción completa

Detalles Bibliográficos
Autores principales: Williams II, Benfeard, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623519/
https://www.ncbi.nlm.nih.gov/pubmed/26506597
http://dx.doi.org/10.1371/journal.pcbi.1004359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623519/
https://www.ncbi.nlm.nih.gov/pubmed/26506597
http://dx.doi.org/10.1371/journal.pcbi.1004359

Ejemplares similares