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Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1)
Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynam...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623604/ https://www.ncbi.nlm.nih.gov/pubmed/26507530 http://dx.doi.org/10.1038/srep15686 |