Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis

Infection with cagA-positive Helicobacter pylori is critically associated with the development of gastric cancer. The cagA-encoded CagA is delivered into gastric epithelial cells via type IV secretion, where it interacts with and thereby deregulates the pro-oncogenic phosphatase SHP2. East Asian Cag...

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Detalles Bibliográficos
Autores principales: Nagase, Lisa, Hayashi, Takeru, Senda, Toshiya, Hatakeyama, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623810/
https://www.ncbi.nlm.nih.gov/pubmed/26507409
http://dx.doi.org/10.1038/srep15749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623810/
https://www.ncbi.nlm.nih.gov/pubmed/26507409
http://dx.doi.org/10.1038/srep15749

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